Menu

Research

Research overview-

Mycobacteria, including Mycobacterium tuberculosis and Mycobacterium bovis are extremely successful pathogens with the former afflicting more than one-third of the human population. Upon infection with M. tuberculosis, only about 10% of the infected populace goes on to develop active tuberculosis (TB) disease. The rest exhibit a clinically latent infection characterized by the persistence of, possibly, dormant bacilli. Approximately 10% of latently infected individuals progress to a highly contagious disease state, called reactivation TB. The reactivation risk is higher when confounded by immune-suppression, for example, upon co-infection with HIV/AIDS. The host-pathogen interplay is complex. Our research interest lies in studying the immunological parameters associated with host- Mycobacterium tuberculosis interactions during pulmonary-, latent- and reactivation TB. We are also investigating the signaling pathways and immunological responses orchestrated by various pathogen recognition receptors (PRRs) like Toll-like receptors (TLRs), NOD-like receptors (NLRs) and C-type lectin receptors (CLRs) viz Dectin-1. Mycobacteria-responsive epigenetic regulation of immune responses is another area of our interest.

Group MemberĀ 

Bharat Bhatt

Bharat Bhatt

PhD Student

Year of joining IISc: 2014
Masters: M.Sc. (Biotechnology),
Indian Institute of Technology Bombay, Maharashtra
email ID: bharatbhatt[at]iisc.ac.in
Preeti Yadav

Preeti Yadav

PhD Student

Year of joining IISc: 2014
Masters: M.Sc.(Life Sciences),
School of Life Sciences, Jawaharlal Nehru University, Delhi
email ID: preetiyadav[at].ac.in

Salik Miskat Borbora

Salik Miskat Borbora

PhD Student

Year of Joining IISc: 2015
Masters: M.Sc. (Molecular Biology and Biotechnology),
Tezpur University, Tezpur, Assam
email ID: salikborbora[at]iisc.ac.in

Ankita Ghoshal

Ankita Ghoshal

PhD Student

Year of Joining IISc: 2018
Masters: M.Sc. (Microbiology),
Banaras Hindu University, UP
email ID: ankitag[at]iisc.ac.in

Ashish Bijewar

Ashish Bijewar

PhD Student

Year of Joining IISc: 2017
Masters: M.Sc. (Biotechnology),
Dr. Baba Saheb Ambedkar Marathwada University, Aurangabad, Maharashtra
email ID: ashishb[at]iisc.ac.in

Mahima

Mahima

PhD Student

Year of Joining IISc: 2018
Masters: M.Sc. (Life Sciences),
School of Life Sciences, Jawaharlal Nehru University, Delhi
email ID: mahima16331[at]iisc.ac.in

Ankita Ghoshal

Ankita Ghoshal

PhD Student

Year of Joining IISc: 2018
Masters: M.Sc. (Microbiology), Banaras Hindu University, UP
email ID: ankitag[at]iisc.ac.in

Awantika Shah

Awantika Shah

Int. PhD Student

Year of joining IISc: 2018
Bachelors: B.Sc. (Biotechnology),
Fergusson College, Pune University, Maharashtra
email ID: awantikashah[at]iisc.ac.in

Parul Gupta

Parul Gupta

PhD Student

Year of Joining IISc: 2019
Masters: BS-MS dual degree (Biological Sciences),
IISER, Bhopal, Madhya Pradesh
email ID: gparul[at]iisc.ac.in

Sneha Bhatt

Sneha Bhatt

Project Assistant

Year of Joining: 2019
Masters: M.Sc.(Microbiology), Mount Carmel College, Bangalore, Karnataka
email ID: snehabhatt[at]iisc.ac.in

Alumni

Dr.Yeddula Narayana
Dr.Kanhu C. Mishra
Dr. Rashmi Chaturvedi
Dr.Kushagra Bansal
Dr. Nisha Kapoor
Dr.Akhauri Yash Sinha
Dr.DevramSampatGhorpade
Dr.JammaTrinath
Dr.Sahana Holla
Dr. M. Ravinder Naick
Dr. Vikas Singh
Dr.MonoranjanBoro
Dr. Praveen Prakhar
Dr. Kasturi Mahadik

K. N. Balaji

K. N. Balaji

PROFESSOR

Email: balaji@iisc.ac.in

Publications